2010: the year in review

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Faithful readers will notice that we had a long hiatus here as I completed my dissertation and then recovered from the resulting snake-fight injuries. Meanwhile, the year 2010 saw a number of landmark papers and subtle shifts in the scientific terrain.
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Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration.

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Glenn Dumont and colleagues have an excellent new paper in social neuroscience showing that 100 mg MDMA increases oxytocin and prosocial feelings in people a controlled laboratory setting. It’s about time someone properly confirmed this theory!
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Johansen and Krebs paper on ‘How could MDMA (ecstasy) help anxiety disorders?’

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Pål Johansen and Teri Krebs have published a short Perspective paper hypothesizing three potential mechanisms by which MDMA might be helpful in anxiety disorders.
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Advisory Council on the Misuse of Drugs report on Ecstasy

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In the UK, the Advisory Council on the Misuse of Drugs (ACMD) has written a review of MDMA (‘ecstasy’), its harms and its legal classification.
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Current Psychedelic Research in Patient Populations

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Here is a list of four human psychedelic studies that are currently recruiting participants. These are all seeking people with specific illnesses. Most of these details were obtained from ClinicalTrials.gov and maps.org
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Current Psychedelic Research in Healthy Volunteers

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Here are two human psychedelic studies that are currently no longer recruiting participants healthy psychedelic-experienced volunteers. (Full disclosure: I am involved in conducting both of these studies.) In a separate entry, I list the studies that are seeking people with specific illnesses who can be psychedelic-naive. Most of the details on these other studies were obtained from ClinicalTrials.gov and maps.org
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MDMA and Hyponatremia

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Dumont and colleagues have published a paper in which they describe the physiological effects of giving MDMA along with alcohol to people. One of the interesting things about this paper is that they measured plasma concentrations of antidiuretic hormone (ADH). (ADH is the hormone that causes the kidneys to conserve water, thus regulating the water balance in the body.)
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or maybe it was just the LSD?

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The Nature News piece on MDMA and PTSD (see my blog entry) wrote:

Swiss psychiatrists have previously reported data on MDMA use in a therapeutic context, but the subjects also received LSD psychotherapy. Although the results were broadly positive, it was not possible to separate the effects of each drug.

Did Nature News really just say that old reports don’t let us conclude MDMA psychotherapy works since maybe it was just the LSD?!

And in any case, isn’t the only citation for those Swiss data the MAPS newsletter?

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